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CCR4 antagonist 3-1
CAS No. 1957-01-3
CCR4 antagonist 3-1( —— )
Catalog No. M35402 CAS No. 1957-01-3
CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 141 | Get Quote |
|
| 5MG | 217 | Get Quote |
|
| 10MG | 353 | Get Quote |
|
| 25MG | 670 | Get Quote |
|
| 50MG | 1040 | Get Quote |
|
| 100MG | 1377 | Get Quote |
|
| 500MG | 2673 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCCR4 antagonist 3-1
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NoteResearch use only, not for human use.
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Brief DescriptionCCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM.
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DescriptionCCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM).
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In Vitro——
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In VivoCCR4 antagonist 3 (compound 1) (0.5 mg/kg for IV; 2 mg/kg for PO; single dosage) exhibits a high clearance, short half-life and low oral bioavailability.Animal Model:Rats Dosage:0.5 mg/kg for IV; 2 mg/kg for PO Administration:IV and PO; single dosage Result:Exhibited a high clearance of 4.2 L/h/kg and a short half-life of 0.4 h, and the oral bioavailability of 2%.
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Synonyms——
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PathwayAutophagy
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TargetCCR
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RecptorCCR
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Research Area——
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Indication——
Chemical Information
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CAS Number1957-01-3
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Formula Weight240.32
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Molecular FormulaC14H12N2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (260.07 mM; Ultrasonic )
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SMILESN(C=1C2=C(C=CC1)C=CC=C2)C3=NC(C)=CS3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang X, et al. Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3.?
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